Journal article
Austin T. Thiel, Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, Zuguo Liu, P. Ernst, G. Koretzky, X. Hua
Cancer Cell, 2010
Cancer Cell, 2010
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APA
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Thiel, A. T., Blessington, P., Zou, T., Feather, D., Wu, X., Yan, J., … Hua, X. (2010). MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele. Cancer Cell.
Chicago/Turabian
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Thiel, Austin T., Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, et al. “MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele.” Cancer Cell (2010).
MLA
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Thiel, Austin T., et al. “MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele.” Cancer Cell, 2010.
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@article{austin2010a,
title = {MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele},
year = {2010},
journal = {Cancer Cell},
author = {Thiel, Austin T. and Blessington, Peter and Zou, Tao and Feather, Danielle and Wu, Xinjiang and Yan, Jizhou and Zhang, Hui and Liu, Zuguo and Ernst, P. and Koretzky, G. and Hua, X.}
}
Abstract
SUMMARY Oncogenic fusion proteins are capable of initiating tumorigenesis but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, resulting in the formation of oncogenic MLL fusion proteins (MLL-FPs). Here we show that menin recruits both wild-type (wt) MLL and MLL-AF9 to the loci of Hox genes to activate their transcription. Wild-type MLL not only catalyzes histone methylation at key target genes but also controls distinct MLL-AF9-induced histone methylation. Notably, the wt Mll allele is required for MLL-AF9-induced leukemogenesis and maintenance of MLL-AF9-transformed cells. These findings suggest an essential cooperation between an oncogene and its wild-type counterpart in MLL-AF9-induced leukemogenesis.