Comprehensive molecular and functional analysis of NUTM1-rearranged leukemia
Koutarou Nishimura, Tomoya Isobe, Tsukasa Shigehiro, Masaki Nomura, Weijia Zang, Muran Xiao, Wenjuan Liao, Yui Koike, Akira Nishimura, A. Sato-Otsubo, Hiromi Yamazaki, Hiromi Ito, Shinri Okada, Naomi Matsumoto, Wataru Saika, Yifan Zhang, Yumi Aoyama, Chihiro Hasegawa, Takaya Yamasaki, Yasuo Kubota, Kentaro Oki, N. Kiyokawa, G. Nagae, Kenichi Yoshida, Y. Nannya, Hiroo Ueno, Shiro Fukuda, K. Tatsuno, S. Tsutsumi, Yusuke Shiozawa, Y. Shiraishi, K. Chiba, Hiroko Tanaka, Mariko Eguchi, Yuki Arakawa, K. Koh, Takao Deguchi, Daisuke Tomizawa, T. Miyamura, Eiichi Ishii, Shuki Mizutani, Satoru Miyano, Hiroyuki Aburatani, Seishi Ogawa, A. Takaori-Kondo, Akihiko Yokoyama, Omar Abdel-Wahab, Patricia Ernst, Junko Takita, Tomokatsu Ikawa, Masatoshi Takagi, Daichi Inoue
Blood, 2025
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation
K. R. Vann, Rajal Sharma, Chih-Chao Hsu, Maëva Devoucoux, A. Tencer, Lei Zeng, Kevin Lin, Li Zhu, Qin Li, C. Lachance, Ruben Rosas Ospina, Qiong Tong, Ka Lung Cheung, Shuai Yang, Soumi Biswas, Hongwen Xuan, J. Gatchalian, Lorena Alamillo, Jianlong Wang, S. Jang, B. J. Klein, Yue Lu, Patricia Ernst, B. Strahl, Scott B. Rothbart, M. Walsh, Michael L. Cleary, Jacques Côté, Xiaobing Shi, Ming-Ming Zhou, T. Kutateladze
Nature Communications, 2025
KMT2A-rearranged leukemia: from mechanism to drug development
Patricia Ernst, Perpetual Kyei, Akihiko Yokoyama
Experimental Hematology, 2025
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
C. Sparbier, Andrea Gillespie, Juliana Gomez, N. Kumari, A. Motazedian, K. Chan, Charles C. Bell, O. Gilan, Yih-Chih Chan, S. Popp, Daniel J. Gough, M. Eckersley-Maslin, S. Dawson, P. Lehner, K. Sutherland, P. Ernst, G. McGeehan, E. Lam, M. Burr, M. Dawson
Nature Cell Biology, 2023
Menin is necessary for long term maintenance of meningioma-1 driven leukemia
Clara Libbrecht, H. Xie, Molly C. Kingsley, Jessica N Haladyna, Simone S. Riedel, Fatemeh Alikarami, Alexandra Lenard, G. McGeehan, P. Ernst, K. Bernt
Leukemia, 2021
D. Rogawski, Jing Deng, Hao Li, H. Miao, D. Borkin, Trupta Purohit, Jiho Song, Jennifer Chase, Shuangjiang Li, Juliano Ndoj, Szymon Kłossowski, EunGi Kim, Fengbiao Mao, Bo Zhou, James Ropa, Marta Z Krotoska, Zhuang Jin, P. Ernst, Xiaomin Feng, Gang Huang, K. Nishioka, Sean D. Kelly, Miao He, Bo Wen, Duxin Sun, Andrew G Muntean, Y. Dou, I. Maillard, T. Cierpicki, J. Grembecka
Nature Communications, 2021
Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
N. Nguyen, K. Gudmundsson, A. Soltis, K. Oakley, K. Roy, Yufen Han, C. Gurnari, J. Maciejewski, G. Crouch, P. Ernst, C. Dalgard, Yang Du
iScience, 2021
Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia
Wenjuan Liao, M. Kohler, T. Fry, P. Ernst
Experimental Hematology, 2021
Weiwei Yang, Weiwei Yang, G. Trahan, Elizabeth D. Howell, N. Speck, Kenneth L. Jones, A. Gillen, K. Riemondy, J. Hesselberth, D. Bryder, D. Bryder, P. Ernst
Stem Cell Reports, 2020
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
C. Hurtz, L. Chan, H. Geng, E. Ballabio, G. Xiao, Gauri Deb, H. Khoury, Chun-Wei Chen, S. Armstrong, Jianjun Chen, P. Ernst, A. Melnick, T. Milne, M. Müschen
Genes & Development, 2019
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
Gregory C Addicks, Gregory C Addicks, Caroline E. Brun, Caroline E. Brun, Marie-Claude Sincennes, Marie-Claude Sincennes, J. Saber, J. Saber, C. J. Porter, A. F. Stewart, P. Ernst, Michael A. Rudnicki, Michael A. Rudnicki
Nature Communications, 2019
P. Ernst, D. Bryder, Kenneth L. Jones, Devon Trahan, Weiwei Yang
Experimental Hematology, 2019
REVISITING THE NF-KAPPAB AXIS IN MLL-REARRANGED LEUKEMIA
T. Vu, Wenjuan Liao, Weiwei Yang, I. Tandon, P. Ernst
Experimental Hematology, 2019
Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation
Yufei Chen, P. Ernst
Cell Cycle, 2019
MLL1 promotes IL-7 responsiveness and survival during B-cell differentiation
Tao Gan, Bin E. Li, B. Mishra, Kenneth L. Jones, P. Ernst
Journal of Immunology, 2018
Gain-of-Function MLL1 Model Distinguishes Hematopoietic From Leukemogenic Pathways
Weiwei Yang, P. Ernst, D. Bryder, Kenneth L. Jones
Experimental Hematology, 2018
Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia
Yufei Chen, Kenneth L. Jones, K. Anastassiadis, A. Kranz, A. Stewart, J. Grembecka, M. Meyerson, P. Ernst
Experimental Hematology, 2018
Distinct functions of H3K4 methyltransferases in normal and malignant hematopoiesis
Weiwei Yang, P. Ernst
Current opinion in hematology, 2017
MLL2, not MLL1, Plays a Major Role in Sustaining MLL-rearranged Acute Myeloid Leukemia
Yufei Chen, Yufei Chen, K. Anastassiadis, A. Kranz, A. F. Stewart, Kathrin Arndt, Claudia Waskow, A. Yokoyama, Kenneth L. Jones, T. Neff, Yoora Lee, P. Ernst
Cancer Cell, 2017
C. Hurtz, L. Chan, E. Ballabio, C. Willman, W. Carroll, S. Armstrong, P. Ernst, A. Melnick, T. Milne, M. Müschen
2016
Erica Y. Shen, Yan Jiang, B. Javidfar, Bibi S. Kassim, Yong-Hwee E Loh, Q. Ma, A. Mitchell, V. Pothula, A. F. Stewart, P. Ernst, W. Yao, Gilles E. Martin, Li Shen, Mira Jakovcevski, S. Akbarian
Neuropsychopharmacology, 2016
NUP98-Fusion Proteins Interact With the NSL and MLL1 Complexes To Drive Leukemogenesis
Haiming Xu, D. Valerio, Meghan E. Eisold, Amit U. Sinha, R. Koche, Wenhuo Hu, C. Chen, S. Chu, Gerard L. Brien, Christopher Y. Park, J. Hsieh, P. Ernst, Scott A. Armstrong
Cancer Cell, 2016
The Role of MLL1 and MLL2 in MLL Fusion Oncoprotein-Initiated Leukemia
P. Ernst, K. Anastassiadis, A. Kranz, A. F. Stewart, Kathrin Arndt, Claudia Waskow, A. Yokoyama, Kenneth L. Jones, T. Neff, Yufei Chen
2016
Role of endogenous histone methyltransferases in leukemia
P. Ernst, Yufei Chen, K. Anastassiadis, A. Krantz, A. Yokoyama, A. F. Stewart, T. Neff, Kenneth L. Jones
2016
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
Simone S. Riedel, Jessica N Haladyna, M. Bezzant, Brett M. Stevens, D. Pollyea, Amit U. Sinha, S. Armstrong, Q. Wei, R. Pollock, S. Daigle, C. Jordan, P. Ernst, T. Neff, K. Bernt
Journal of Clinical Investigation, 2016
Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia.
Tatsuro Watanabe, P. Ernst
Cancer Cell, 2016
Modeling gain-of-function MLL1 to probe HSC self-renewal versus hematologic malignancy
Weiwei Yang, D. Bryder, P. Ernst
2016
SET/MLL family proteins in hematopoiesis and leukemia
Weiwei Yang, P. Ernst
International journal of hematology, 2016
Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets
Wenchu Lin, J. Francis, Hong Li, Xiaoping Gao, C. Pedamallu, P. Ernst, M. Meyerson
Cancer Biology & Therapy, 2016
The combined activity of MLL1 and MLL2 supports leukemogenesis by MLL fusion oncoproteins
Yufei Chen, K. Anastassiadis, A. Kranz, F. Stewart, A. Yokoyama, T. Neff, Kenneth L. Jones, P. Ernst
2016
Mira Jakovcevski, Hongyu Ruan, Erica Y. Shen, Aslihan Dincer, B. Javidfar, Q. Ma, C. Peter, I. Cheung, A. Mitchell, Yan Jiang, C. L. Lin, V. Pothula, A. F. Stewart, P. Ernst, W. Yao, S. Akbarian
Journal of Neuroscience, 2015
Meningeoma-1 Cooperates with MLL and DOT1L to Induce Leukemia
Simone S. Riedel, Jessica N Haladyna, Brett M. Stevens, C. Jordan, D. Pollyea, S. Armstrong, Q. Wei, P. Ernst, T. Neff, K. Bernt
2015
Yufei Chen, Bin E. Li, A. Yokoyama, P. Ernst
2015
Bin E. Li, P. Ernst
Experimental Hematology, 2014
The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
B. Mishra, K. Zaffuto, Erika L. Artinger, T. Org, H. Mikkola, Chao Cheng, M. Djabali, P. Ernst
Cell Reports, 2014
Deconvoluting MLL1-dependent pathways in hematopoiesis and leukemogenesis.
B. Mishra, P. Ernst
Leukemia Supplements, 2014
Daniel L Brook, N. Zorko, A. Dorrance, D. Yanes, K. Bernot, S. Whitman, E. Ahmed, Kathleen McConnell, P. Ernst, Gang Huang, G. Marcucci, M. Caligiuri
2014
CONSERVED HIGHER ORDER CHROMATIN REGULATES NMDA RECEPTOR GENE EXPRESSION AND COGNITION
Rahul A. Bharadwaj, C. Peter, Yan Jiang, P. Roussos, Annie Vogel-Ciernia, Erica Y. Shen, A. Mitchell, Wenjie Mao, Catheryne Whittle, Aslihan Dincer, Mira Jakovcevski, V. Pothula, T. Rasmussen, S. Giakoumaki, P. Bitsios, A. Sherif, P. Gardner, P. Ernst, S. Ghose, P. Sklar, V. Haroutunian, C. Tamminga, R. Myers, K. Futai, M. Wood, S. Akbarian
Neuron, 2014
Endogenous MLL1 is dispensable for the maintenance of MLL-rearranged leukemia
Yufei Chen, Bin E. Li, B. Mishra, P. Ernst
2014
Bin E. Li, Tao Gan, M. Meyerson, T. Rabbitts, P. Ernst
2013
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Bin E. Li, Tao Gan, M. Meyerson, T. Rabbitts, P. Ernst
Blood, 2013
MLL1-dependent pathways and mechanisms that maintain hematopoiesis
Erika L. Artinger, B. Mishra, Bin E. Li, K. Zaffuto, Chao Cheng, T. Org, H. Mikkola, M. Djabali, P. Ernst
2013
An MLL-dependent network sustains hematopoiesis
Erika L. Artinger, B. Mishra, K. Zaffuto, Bin E. Li, E. Y. Chung, A. Moore, Yufei Chen, Chao Cheng, P. Ernst
Proceedings of the National Academy of Sciences of the United States of America, 2013
Cell context in the control of self-renewal and proliferation regulated by MLL1
Erika L. Artinger, P. Ernst
Cell Cycle, 2013
Li‐Hao Huang, Jingang Gui, Erika L. Artinger, R. Craig, B. Berwin, P. Ernst, C. Chang, Ta-Yuan Chang
Arteriosclerosis, Thrombosis and Vascular Biology, 2013
WRAD: enabler of the SET1-family of H3K4 methyltransferases.
P. Ernst, C. Vakoc
Briefings in Functional Genomics, 2012
Coordinating Self-Renewal and Proliferation via MLL1-HOX Pathways and Beyond
P. Ernst, Erika L. Artinger, B. Mishra, K. Zaffuto, Bin E. Li, Yufei Chen
2012
R. Stan, D. Tse, S. Deharvengt, N. Smits, Yan Xu, M. Luciano, C. McGarry, M. Buitendijk, Krishnamurthy V. Nemani, R. Elgueta, Takashi Kobayashi, Samantha L. Shipman, K. Moodie, C. Daghlian, P. Ernst, Hong‐Kee Lee, A. Suriawinata, A. Schned, D. Longnecker, S. Fiering, R. Noelle, B. Gimi, N. Shworak, C. Carrière
Developmental Cell, 2012
Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells
Xiongwei Cai, J. Gaudet, J. Mangan, Michael J. Chen, M. D. De Obaldia, Z. Oo, P. Ernst, N. Speck
PLoS ONE, 2011
MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele
Austin T. Thiel, Peter Blessington, Tao Zou, Danielle Feather, Xinjiang Wu, Jizhou Yan, Hui Zhang, Zuguo Liu, P. Ernst, G. Koretzky, X. Hua
Cancer Cell, 2010
Developmentally-induced Mll1 loss reveals defects in postnatal haematopoiesis
Tao Gan, C. Jude, K. Zaffuto, P. Ernst
Leukemia, 2010
Blaine W. Robinson, Yuanquan Song, G. Germano, P. Ernst, J. Abrams, M. Scott, Amy Kugath, M. Helfrich, J. Sunyer, J. Rhodes, R. Balice-Gordon, C. Felix
2009
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
D. Lim, Yin-Cheng Huang, T. Swigut, Anika L. Mirick, J. García-Verdugo, J. Wysocka, P. Ernst, A. Álvarez-Buylla
Nature, 2009
IFN-alpha wakes up sleeping hematopoietic stem cells
Emanuelle Passegué, P. Ernst
Nature Medicine, 2009
Leukemia and hematopoietic stem cells: Balancing proliferation and quiescence
C. Jude, J. Gaudet, N. Speck, P. Ernst
Cell Cycle, 2008
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.
C. Jude, Leslie K. Climer, Diyong Xu, Erika L. Artinger, J. Fisher, P. Ernst
Cell Stem Cell, 2007
Dimple Bansal, C. Scholl, Stefan Frohling, Elizabeth Mcdowell, Benjamin H. Lee, K. Dohner, P. Ernst, A. Davidson, G. Daley, Leonard I. Zon, D. Gilliland, B. Huntly
Proceedings of the National Academy of Sciences of the United States of America, 2006
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease
Jing Wang, H. Iwasaki, A. Krivtsov, P. Febbo, A. Thorner, P. Ernst, E. Anastasiadou, J. Kutok, S. Kogan, S. Zinkel, J. Fisher, J. Hess, T. Golub, S. Armstrong, K. Akashi, S. Korsmeyer
EMBO Journal, 2005
Embryonic stem cell-derived hematopoietic stem cells.
Y. Wang, F. Yates, O. Naveiras, P. Ernst, G. Daley
Proceedings of the National Academy of Sciences of the United States of America, 2005
Definitive hematopoiesis requires the mixed-lineage leukemia gene.
P. Ernst, J. Fisher, W. Avery, Stacey F. Wade, Dan Foy, S. Korsmeyer
Developmental Cell, 2004
An Mll-dependent Hox program drives hematopoietic progenitor expansion.
P. Ernst, M. Mabon, A. Davidson, L. Zon, S. Korsmeyer
Current Biology, 2004
Derivation of Hematopoietic Stem Cells from Embryonic Stem Cells.
Yuan Wang, Yuan Wang, F. Yates, F. Yates, E. Dikovskaia, E. Dikovskaia, P. Ernst, A. Davidson, L. Zon, G. Daley, G. Daley
2004
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
A. Davidson, P. Ernst, Y. Wang, M. Dekens, P. Kingsley, J. Palis, S. Korsmeyer, G. Daley, L. Zon
Nature, 2003
J. Hsieh, P. Ernst, H. Erdjument‐Bromage, P. Tempst, S. Korsmeyer
Molecular and Cellular Biology, 2003
The role of MLL in hematopoiesis and leukemia
P. Ernst, Jing Wang, S. Korsmeyer
Current opinion in hematology, 2002
MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein
P. Ernst, Jing Wang, M. Huang, R. Goodman, S. Korsmeyer
Molecular and Cellular Biology, 2001
R. D. Hanson, Jay L. Hess, Benjamin D. Yu, P. Ernst, P. Ernst, M. Lohuizen, Anton Berns, N. V. D. Lugt, C. Shashikant, F. Ruddle, M. Seto, S. Korsmeyer, S. Korsmeyer
Proceedings of the National Academy of Sciences of the United States of America, 1999
K. Hahm, P. Ernst, K. Lo, G. Kim, C. Turck, S. Smale
Molecular and Cellular Biology, 1994